Discovery & optimization

Delivering high quality and high affinity antibodies

Polpharma Biologics early stage antibody discovery and humanization platforms are designed to get you a high affinity antibody with the desired binding properties and functional activity that is ready for the next stage of your project. We can also create transient and stable cell lines to provide adequate material for early stage studies.

Monoclonal Antibody Generation with our proprietary CASH™ platform

Our proprietary discovery and development platform (CASH™) is used to generate highly specific monoclonal antibodies with strong affinity. It can be used to generate antibodies against a variety of antigens and generate antibodies in a variety of formats.

  • Generation of antibodies in rodents using the CASH™ platform (Custom Assays for Specific Hybridomas)
  • Hybridoma selection using custom developed bioassays
  • cDNA sequence (DNA) coding for VH and VL and subsequently expressed on human IgG constant region
  • Sequences immunogenicity and manufacturability assessed

Bioassay toolbox for therapeutic assessment and characterization

Extensive assessment technologies

Polpharma Biologics bioassay team offers a range of standardised cell-based assays that can be customised to your specific requirements. We also design bespoke assays to meet the requirements for novel biologics, targets and mechanisms.

  • Flow cytometry
  • ELISA
  • Functional proprietary cell-based assays, including proprietary membrane FcγR- and FcRn-based binding assays
  • ADCC (using a proprietary effector cell line) and CDC
  • Immunogenicity and cytokine release assays
  • Potency assays

Best in class antibody humanization

Polpharma Biologics have been humanizing antibodies for decades using best-in class-technology. We can humanize your antibody rapidly to produce multiple variants for selection.

  • Design best-in-class humanized antibodies
  • More than 200 mAbs have been humanized using this technology. Fifteen out of the ~40 FDA-approved mAbs have been humanized using this method.
  • In silico analysis and sequences are available in 1 month. Wet work takes 4-5 months.
  • No royalties and license fees

Working with us

“We are committed to positive outcomes and delivering projects on time to specification”

We are very happy to work with you on either a standalone project or as part of an integrated project to accelerate your therapeutic to patients. Either way we treat every project equally and are dedicated to delivering results and getting your therapeutic to patients.

Contact us

Let’s collaborate and create quality biologics together.

Get in touch for more information.